The nRF21540 DK is equipped with an IF Boot/Reset button (SW5).
The button is also used to enter the bootloader mode of the interface MCU. To enter the bootloader mode, keep the reset button pressed while powering up the DK until LED5 starts to blink. You can power up the DK either by disconnecting and reconnecting the Universal Serial Bus (USB) cable or by toggling the power switch (SW8).